MAP1LC3B2

Across TCGA patient cohorts, MAP1LC3B2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP1LC3B2-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and Caspase-8. Each is linked with MAP1LC3B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP1LC3B2-to-partner and partner-to-MAP1LC3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by MAP1LC3B2-low versus MAP1LC3B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP1LC3B2→partner) and Y-score (partner→MAP1LC3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.575	+2.827	.037	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+1.085	+3.019	<.001	.019	3	1
UCEC	Caspase-8 →	-0.298	-2.973	.023	.035	3	1
UCEC	4E-BP1 →	+0.342	+2.837	.016	.035	3	1
UCEC	EGFR_pY1068 →	-0.264	-3.321	.044	.010	2	1
UCEC	eIF4E →	+0.230	+3.321	.037	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Annexin-1 by MAP1LC3B2 expression — UCEC

Explore this box plot interactively →