MAP1LC3B

Across TCGA pan-cancer cohorts, MAP1LC3B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MAP1LC3B data layer compared with 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher MAP1LC3B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP1LC3B expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

ESCA, KIRC, and HNSC are the cancer types where MAP1LC3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Quartile	II,III,IV	0.344	0.604	.007	84	view →
KIRC	OS	Tertile	All	0.729	0.493	<.001	70	view →
HNSC	DFS	Quartile	All	0.242	0.477	.002	61	view →
BLCA	DFS	Quartile	III,IV	0.154	0.373	.003	49	view →
STAD	DFS	Quartile	II,III,IV	0.498	0.841	.001	45	view →
SCLC	DFS	Median	All	0.518	0.722	.008	35	view →
LIHC	OS	Tertile	All	0.413	0.597	.006	26	view →
ACC	DFS	Tertile	All	0.451	0.941	<.001	19	view →
GBM	DFS	Tertile	All	0.175	0.332	<.001	16	view →
LUSC	OS	Quartile	All	0.339	0.485	.007	16	view →
DLBC	DFS	Median	All	0.403	0.917	.017	16	view →
KIRP	OS	Median	III,IV	0.934	0.646	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MAP1LC3B–ESCA (DFS)

Open the ESCA breakdown →