MAP1B

Across TCGA patient cohorts, MAP1B mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP1B-associated genes across cancer lineages are PCNA, eIF4E, and RAD51. Each is linked with MAP1B in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP1B-to-partner and partner-to-MAP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MAP1B-low versus MAP1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP1B→partner) and Y-score (partner→MAP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.215	+1.550	<.001	<.001	3	4
UCEC	eIF4E →	+0.188	+1.841	<.001	<.001	3	3
COAD	RAD51 →	+0.135	+1.774	.011	.008	3	3
UCEC	ATM →	-0.632	-2.169	<.001	<.001	3	3
UCEC	Bcl-2 →	-0.242	-1.514	.004	.012	3	3
COAD	Caspase-7-cleavedD198 →	+0.552	+1.753	.039	.047	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

PCNA by MAP1B expression — UCEC

Explore this box plot interactively →