MAP1A

Across TCGA pan-cancer cohorts, MAP1A Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated MAP1A data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher MAP1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAP1A expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

UCS, STAD, and HNSC are the cancer types where MAP1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.001	0.690	<.001	36	view →
STAD	DFS	Median	III,IV	0.875	0.315	.017	16	view →
HNSC	DFS	Median	II,III,IV	0.206	0.565	.005	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ESCA	OS	Median	All	0.084	0.705	<.001	12	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	8	view →
UCEC	DFS	Median	All	0.922	0.611	.006	8	view →
SARC	DFS	Median	All	0.101	0.632	.011	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →
BLCA	DFS	Median	III,IV	0.828	0.425	.021	5	view →
LIHC	DFS	Median	All	0.156	0.556	.010	3	view →
LUAD	OS	Median	All	1.000	0.685	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

MAP1A–UCS (OS)

Open the UCS breakdown →