MAOB

Across TCGA pan-cancer cohorts, MAOB mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MAOB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAOB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MAOB is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where MAOB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAOB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.713	<.001	11	view →
HNSC	Female	All	−1.682	<.001	11	view →
CCRCC	Female	III,IV	−0.683	<.001	10	view →
LSCC	Male	II,III,IV	−1.595	<.001	9	view →
OV	All	All	−1.678	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MAOB–COAD

Open the COAD breakdown →