MAOA

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MAOA mutation is significantly associated with the RNA expression of many other genes, with 2,211 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAOA-associated genes across cancer lineages are IGHD5-12, MFSD12, and SMIM12. Each is linked with MAOA in more than 2 cancer types. Because this analysis shows association rather than direction, both MAOA-to-partner and partner-to-MAOA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAOA→partner) and Y-score (partner→MAOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECIGHD5-12 →+0.386+2.922<.001<.00133
UCECMFSD12 →+0.582+2.233<.001<.00132
UCECSMIM12 →+0.300+2.649.005.00532
UCECUSP36 →+0.285+2.839.008.00132
UCECRASSF1 →+0.367+3.628<.001.00132
UCECRNF126 →+0.446+2.233<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,211 associations by consensus.

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