Across TCGA patient cohorts, MAOA mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAOA-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with MAOA in more than 1 cancer types. Because this analysis shows association rather than direction, both MAOA-to-partner and partner-to-MAOA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAOA→partner) and Y-score (partner→MAOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.075	-2.295	.033	.033	3	1
UCEC	A-Raf_pS299 →	-0.087	-2.000	.038	.030	3	1
UCEC	ERK2 →	+0.179	+2.415	.008	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.144	-1.807	.015	.025	3	1
UCEC	JNK2 →	+0.151	+2.196	.031	.032	3	1
UCEC	MSH2 →	-0.247	-2.196	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

MAOA survival (RNA) · tumor vs normal (RNA) · all MAOA data types