Across TCGA cell cohorts, MAOA mutation is significantly associated with the mutation status of many other genes, with 2,264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAOA-associated genes across cancer lineages are EP300, USP28, and POU6F2. Each is linked with MAOA in more than 2 cancer types. Because this analysis shows association rather than direction, both MAOA-to-partner and partner-to-MAOA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAOA→partner) and Y-score (partner→MAOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EP300 →	+2.672	+4.225	.008	.008	1	3
OVARY	USP28 →	+5.415	+5.415	.004	.004	1	3
OVARY	POU6F2 →	+4.415	+4.977	.007	.007	1	3
BREAST	HJURP →	+4.857	+4.297	.009	.009	1	3
OVARY	GPR171 →	+5.415	+5.415	.004	.004	1	3
LARGE_INTESTINE	NUMA1 →	+1.478	+3.408	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,264 associations by consensus.

Exploration

MAOA survival (RNA) · tumor vs normal (RNA) · all MAOA data types