Across TCGA patient cohorts, MANSC4 mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANSC4-associated genes across cancer lineages are AP1S3, DDX19B, and C12orf43. Each is linked with MANSC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MANSC4-to-partner and partner-to-MANSC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANSC4→partner) and Y-score (partner→MANSC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP1S3 →	+0.814	+3.638	<.001	.001	3	1
UCEC	DDX19B →	+0.421	+3.377	.001	.004	3	1
UCEC	C12orf43 →	+0.372	+3.595	.003	.001	3	1
UCEC	SLC45A1 →	-0.596	-3.584	.002	.003	3	1
UCEC	SNED1 →	-0.778	-3.443	.002	.005	3	1
UCEC	GNL3 →	+0.567	+3.329	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

Exploration

MANSC4 survival (RNA) · tumor vs normal (RNA) · all MANSC4 data types