Across TCGA patient cohorts, MANSC4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANSC4-associated genes across cancer lineages are EGFR_pY1068, ACC1, and Tuberin. Each is linked with MANSC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MANSC4-to-partner and partner-to-MANSC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANSC4→partner) and Y-score (partner→MANSC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.279	-3.169	.043	.020	3	1
UCEC	ACC1 →	+0.551	+2.820	.005	.035	3	1
UCEC	Tuberin →	+0.330	+2.817	.025	.036	3	1
UCEC	ASNS →	+0.530	+3.169	.007	.020	3	1
UCEC	ATM →	-0.548	-3.169	.027	.020	3	1
UCEC	PCNA →	+0.256	+3.169	.030	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

MANSC4 survival (RNA) · tumor vs normal (RNA) · all MANSC4 data types