MANSC1

Across TCGA pan-cancer cohorts, MANSC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MANSC1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MANSC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MANSC1 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

LSCC, COAD, and PDAC are the cancer types where MANSC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.606	0.891	.023	11	view →
COAD	DFS	Median	II,III,IV	1.000	0.825	.047	6	view →
PDAC	DFS	Median	II,III,IV	0.646	0.388	.035	6	view →
GBM	DFS	Median	All	0.881	0.580	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MANSC1–LSCC (OS)

Open the LSCC breakdown →