MANSC1

Across TCGA patient cohorts, MANSC1 mutation is significantly associated with the RNA expression of many other genes, with 675 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANSC1-associated genes across cancer lineages are POLE2, E2F1, and NUP93. Each is linked with MANSC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MANSC1-to-partner and partner-to-MANSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by MANSC1-low versus MANSC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANSC1→partner) and Y-score (partner→MANSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.706	+3.480	<.001	.002	3	2
UCEC	E2F1 →	+0.813	+2.332	.004	.003	3	2
UCEC	NUP93 →	+0.446	+3.332	.005	.005	3	2
UCEC	VAC14 →	+0.463	+3.032	<.001	<.001	3	2
UCEC	AAGAB →	+0.444	+2.593	.005	.006	3	2
UCEC	SGTA →	+0.443	+2.871	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 675 associations by consensus.

POLE2 by MANSC1 expression — UCEC

Explore this box plot interactively →