MANSC1

Across TCGA patient cohorts, MANSC1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANSC1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, INPP4B, and Notch1. Each is linked with MANSC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MANSC1-to-partner and partner-to-MANSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by MANSC1-low versus MANSC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANSC1→partner) and Y-score (partner→MANSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.493	+2.000	.031	.032	3	2
UCEC	INPP4B →	-0.290	-2.999	.047	.035	3	2
UCEC	Notch1 →	+0.206	+2.331	.001	.019	3	2
SKCM	Src →	-0.294	-3.169	.019	.019	3	1
UCEC	MEK1 →	+0.445	+2.321	.006	.034	3	1
UCEC	VHL →	-0.618	-2.000	.043	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Acetyl-a-Tubulin-Lys40 by MANSC1 expression — UCEC

Explore this box plot interactively →