MANSC1

Across TCGA cell cohorts, MANSC1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MANSC1-associated genes across cancer lineages are REG1B, PRAMEF20, and KRTAP10-1. Each is linked with MANSC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MANSC1-to-partner and partner-to-MANSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by MANSC1-low versus MANSC1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANSC1→partner) and Y-score (partner→MANSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG1B →	+1.004	+5.169	<.001	.005	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.013	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR5V1 →	+0.013	+6.022	<.001	.001	3	1
LARGE_INTESTINE	CCL18 →	+0.129	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

REG1B by MANSC1 expression — BREAST

Explore this box plot interactively →