Across TCGA pan-cancer cohorts, MANEAL mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MANEAL data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher MANEAL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MANEAL expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, CCRCC, and LSCC are the cancer types where MANEAL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.855	0.607	.008	6	view →
CCRCC	DFS	Median	II,III,IV	0.284	1.000	.013	4	view →
LSCC	DFS	Median	All	1.000	0.582	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MANEAL tumor-vs-normal RNA expression · all MANEAL data types