Across TCGA patient cohorts, MANEAL RNA expression is significantly associated with the protein abundance of many other proteins, with 9,861 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MANEAL-associated proteins across cancer lineages are GDAP1, GDAP1_S11, and BICD2. Each is linked with MANEAL in more than 3 cancer types. Because this analysis shows association rather than direction, both MANEAL-to-partner and partner-to-MANEAL results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEAL→partner) and Y-score (partner→MANEAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GDAP1 →	+0.999	+0.783	<.001	.003	3	4
BRCA	GDAP1_S11 →	+1.044	+0.609	<.001	.004	3	4
HNSC	BICD2 →	-0.487	-0.858	.001	.001	3	3
HNSC	BICD2_S823 →	-1.051	-0.948	<.001	.001	3	3
HNSC	FAM169A →	+0.549	+0.541	<.001	.001	3	3
GBM	GFPT2 →	-0.636	-0.614	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,861 associations by consensus.

Exploration

MANEAL survival (RNA) · tumor vs normal (RNA) · all MANEAL data types