Across TCGA patient cohorts, MANEAL protein abundance is significantly associated with the RNA expression of many other genes, with 7,709 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MANEAL-associated genes across cancer lineages are HINFP, HIPK2, and UBE4A. Each is linked with MANEAL in more than 2 cancer types. Because this analysis shows association rather than direction, both MANEAL-to-partner and partner-to-MANEAL results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEAL→partner) and Y-score (partner→MANEAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HINFP →	+1.080	+1.107	<.001	.004	3	3
HNSC	HIPK2 →	+1.319	+0.998	.003	.002	3	3
HNSC	UBE4A →	+0.683	+0.689	<.001	.003	3	2
HNSC	DDX6 →	+0.522	+0.713	<.001	.004	3	2
HNSC	CBL →	+0.964	+1.028	.002	.008	3	2
HNSC	CNOT6 →	+0.550	+0.694	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,709 associations by consensus.

Exploration

MANEAL survival (RNA) · tumor vs normal (RNA) · all MANEAL data types