Across TCGA patient cohorts, MANEAL mutation is significantly associated with the RNA expression of many other genes, with 569 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MANEAL-associated genes across cancer lineages are TPT1P11, MIR8075, and RNU4-9P. Each is linked with MANEAL in more than 2 cancer types. Because this analysis shows association rather than direction, both MANEAL-to-partner and partner-to-MANEAL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEAL→partner) and Y-score (partner→MANEAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TPT1P11 →	+0.083	+5.418	<.001	.005	3	3
UCEC	MIR8075 →	+0.932	+2.694	<.001	.003	3	2
HNSC	RNU4-9P →	+0.351	+5.303	<.001	.006	3	2
COAD	PCNPP3 →	+0.235	+4.151	.007	.001	3	2
COAD	MIR548K →	+0.527	+3.321	.006	.008	3	2
COAD	RPSAP65 →	+0.088	+4.020	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 569 associations by consensus.

Exploration

MANEAL survival (RNA) · tumor vs normal (RNA) · all MANEAL data types