Across TCGA cell cohorts, MANEAL mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MANEAL-associated genes across cancer lineages are C6orf118, ITGAD, and FANCD2OS. Each is linked with MANEAL in more than 1 cancer types. Because this analysis shows association rather than direction, both MANEAL-to-partner and partner-to-MANEAL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANEAL→partner) and Y-score (partner→MANEAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.130	+3.115	<.001	.004	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	FANCD2OS →	+0.145	+3.667	<.001	.003	3	1
LARGE_INTESTINE	OR1L6 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SPEM2 →	+0.054	+3.989	<.001	.001	3	1
LARGE_INTESTINE	IFIT1B →	+0.025	+3.145	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

MANEAL survival (RNA) · tumor vs normal (RNA) · all MANEAL data types