MANEA

Across TCGA pan-cancer cohorts, MANEA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MANEA data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MANEA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MANEA expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where MANEA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.776	0.338	.002	18	view →
LSCC	DFS	Median	All	1.000	0.444	.002	9	view →
HNSC	DFS	Quartile	All	0.352	1.000	.045	8	view →
CCRCC	OS	Median	All	0.983	0.896	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MANEA–PDAC (OS)

Open the PDAC breakdown →