MANCR

Across TCGA patient cohorts, MANCR RNA expression is significantly associated with the go_rna of many other GO terms, with 7,105 significant associations in total. LGG shows the largest number of these associations.

The most reproducible MANCR-associated GO terms across cancer lineages are Negative regulation of coagulation, Multi-multicellular organism process, and Negative regulation of plasminogen activation. Each is linked with MANCR in more than 20 cancer types. Because this analysis shows association rather than direction, both MANCR-to-partner and partner-to-MANCR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of coagulation grouped by MANCR-low versus MANCR-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MANCR→partner) and Y-score (partner→MANCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Negative regulation of coagulation →	+0.054	+0.158	<.001	<.001	3	21
STAD	Multi-multicellular organism process →	+0.042	+0.303	<.001	<.001	3	21
TGCT	Negative regulation of plasminogen activation →	+0.135	+0.192	<.001	<.001	3	19
TGCT	Regulation of wound healing →	+0.044	+0.176	<.001	<.001	3	19
STAD	Regulation of protein maturation →	+0.048	+0.441	<.001	<.001	3	18
TGCT	Negative regulation of wound healing →	+0.043	+0.171	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,105 associations by consensus.

Negative regulation of coagulation by MANCR expression — TGCT

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