MANBAL

Across TCGA pan-cancer cohorts, MANBAL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MANBAL data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MANBAL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MANBAL expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where MANBAL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.895	0.646	.004	26	view →
PDAC	DFS	Quartile	All	0.252	0.465	.002	12	view →
UCEC	OS	Median	III,IV	0.531	1.000	.030	8	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	7	view →
LUAD	DFS	Quartile	II,III,IV	0.314	0.783	.008	7	view →
LSCC	DFS	Median	All	0.964	0.905	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MANBAL–HNSC (DFS)

Open the HNSC breakdown →