MAN2C1

Across TCGA patient cohorts, MAN2C1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN2C1-associated genes across cancer lineages are eIF4E, Akt_pS473, and Akt_pT308. Each is linked with MAN2C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN2C1-to-partner and partner-to-MAN2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MAN2C1-low versus MAN2C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2C1→partner) and Y-score (partner→MAN2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+3.335	.012	.005	3	2
UCEC	Akt_pS473 →	+0.603	+1.584	.015	.034	3	2
UCEC	Akt_pT308 →	+0.493	+2.584	.024	.010	3	2
UCEC	STAT3_pY705 →	-0.247	-1.838	.006	.007	3	2
UCEC	ATM →	-0.503	-2.209	.001	.009	3	2
UCEC	14-3-3_beta →	-0.129	-3.780	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eIF4E by MAN2C1 expression — UCEC

Explore this box plot interactively →