MAN2C1

Across TCGA cell cohorts, MAN2C1 mutation is significantly associated with the RNA expression of many other genes, with 192 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAN2C1-associated genes across cancer lineages are UROC1, SLC6A19, and OPRPN. Each is linked with MAN2C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN2C1-to-partner and partner-to-MAN2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UROC1 grouped by MAN2C1-low versus MAN2C1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2C1→partner) and Y-score (partner→MAN2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UROC1 →	+0.116	+3.954	<.001	.005	3	2
LARGE_INTESTINE	SLC6A19 →	+1.191	+2.607	<.001	.008	3	2
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	CPN1 →	+0.152	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	KRT71 →	+0.007	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	SLC7A13 →	+0.004	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 192 associations by consensus.

UROC1 by MAN2C1 expression — BLOOD_Lymphoma

Explore this box plot interactively →