MAN2A2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MAN2A2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN2A2-associated genes across cancer lineages are Src, Ku80, and Annexin_VII. Each is linked with MAN2A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN2A2-to-partner and partner-to-MAN2A2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2A2→partner) and Y-score (partner→MAN2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSrc →-0.153-1.584.021.03433
UCECKu80 →+0.211+1.775.005.00732
UCECAnnexin_VII →-0.112-2.212.013.01032
UCECSTAT3_pY705 →-0.272-1.574.001.01732
UCECCaspase-7-cleavedD198 →+0.559+3.107.003<.00132
UCEC4E-BP1 →+0.317+2.936<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration