Across TCGA cell cohorts, MAN2A2 mutation is significantly associated with the RNA expression of many other genes, with 915 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAN2A2-associated genes across cancer lineages are GPR42, OR10W1, and RAD51C. Each is linked with MAN2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN2A2-to-partner and partner-to-MAN2A2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2A2→partner) and Y-score (partner→MAN2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPR42 →	+0.026	+5.369	<.001	.004	3	2
BREAST	OR10W1 →	+0.006	+3.781	<.001	.009	3	2
LARGE_INTESTINE	RAD51C →	+0.907	+3.459	<.001	.001	3	2
LARGE_INTESTINE	EPM2A →	+0.406	+3.321	.007	.003	3	2
LARGE_INTESTINE	OSCP1 →	+0.701	+2.158	<.001	.004	3	2
LARGE_INTESTINE	GLE1 →	+0.329	+2.158	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 915 associations by consensus.

Exploration

MAN2A2 survival (RNA) · tumor vs normal (RNA) · all MAN2A2 data types