MAN1B1-DT

Across TCGA pan-cancer cohorts, MAN1B1-DT RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MAN1B1-DT data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MAN1B1-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAN1B1-DT expression acts as an unfavorable survival marker, although some lineages such as UVM and CHOL show a favorable association.

BLCA, UVM, and CHOL are the cancer types where MAN1B1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.382	0.535	.002	103	view →
UVM	OS	Tertile	II,III,IV	0.865	0.400	<.001	93	view →
CHOL	OS	Tertile	II,III,IV	1.000	0.193	<.001	57	view →
ACC	DFS	Tertile	All	0.223	0.684	<.001	52	view →
LGG	OS	Median	All	0.542	0.369	<.001	47	view →
KIRC	DFS	Median	All	0.704	0.547	<.001	42	view →
KIRP	OS	Quartile	All	0.859	0.521	.001	39	view →
BRCA	OS	Tertile	All	0.985	0.943	.001	37	view →
KICH	OS	Median	III,IV	0.914	0.366	.003	26	view →
UCS	DFS	Quartile	II,III,IV	0.593	0.106	.004	26	view →
THCA	DFS	Median	IV	0.459	0.801	.009	22	view →
PAAD	OS	Median	All	0.600	0.385	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MAN1B1-DT–BLCA (OS)

Open the BLCA breakdown →