Across TCGA patient cohorts, MAN1A2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN1A2-associated genes across cancer lineages are ATM, mTOR_pS2448, and Notch1. Each is linked with MAN1A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN1A2-to-partner and partner-to-MAN1A2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1A2→partner) and Y-score (partner→MAN1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.417	-1.906	.007	.015	3	3
UCEC	mTOR_pS2448 →	-0.109	-1.440	.034	.024	3	2
UCEC	Notch1 →	+0.150	+2.013	.002	.016	3	2
COAD	ETS-1 →	+0.270	+3.025	.028	.019	3	1
COAD	Shc_pY317 →	-0.245	-2.991	.004	.036	3	1
UCEC	A-Raf_pS299 →	-0.110	-1.906	.008	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

MAN1A2 survival (RNA) · tumor vs normal (RNA) · all MAN1A2 data types