Across TCGA cell cohorts, MAN1A2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MAN1A2-associated genes across cancer lineages are SIRPD, HSFY1, and CCR8. Each is linked with MAN1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN1A2-to-partner and partner-to-MAN1A2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1A2→partner) and Y-score (partner→MAN1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIRPD →	+0.058	+5.029	<.001	.006	3	2
SOFT_TISSUE	HSFY1 →	+0.019	+4.635	<.001	.003	3	1
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	GPX6 →	+0.017	+4.369	<.001	.008	3	1
SOFT_TISSUE	TBL1Y →	+0.434	+4.417	<.001	.004	3	1
OESOPHAGUS	CRP →	+0.036	+4.017	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

MAN1A2 survival (RNA) · tumor vs normal (RNA) · all MAN1A2 data types