MAMLD1

Across TCGA patient cohorts, MAMLD1 mutation is significantly associated with the RNA expression of many other genes, with 6,515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAMLD1-associated genes across cancer lineages are CDRT15P7, ATP6V0E1P3, and TMED2-DT. Each is linked with MAMLD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAMLD1-to-partner and partner-to-MAMLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDRT15P7 grouped by MAMLD1-low versus MAMLD1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMLD1→partner) and Y-score (partner→MAMLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDRT15P7 →	+0.066	+3.707	<.001	.004	3	3
LUSC	ATP6V0E1P3 →	+0.151	+2.657	.007	.003	3	3
UCEC	TMED2-DT →	+0.218	+2.627	.001	<.001	3	3
UCEC	PBK →	+0.974	+2.050	<.001	<.001	3	3
UCEC	MRPL19 →	+0.488	+2.959	<.001	<.001	3	3
UCEC	TROAP →	+0.487	+4.258	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,515 associations by consensus.

CDRT15P7 by MAMLD1 expression — BRCA

Explore this box plot interactively →