MAMLD1

Across TCGA patient cohorts, MAMLD1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAMLD1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and P-Cadherin. Each is linked with MAMLD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAMLD1-to-partner and partner-to-MAMLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAMLD1-low versus MAMLD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMLD1→partner) and Y-score (partner→MAMLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.593	+1.671	<.001	.003	3	4
UCEC	Cyclin-B1 →	+0.700	+1.906	<.001	<.001	3	3
UCEC	P-Cadherin →	-0.092	-2.321	.028	.005	3	2
UCEC	PCNA →	+0.225	+1.874	<.001	.002	3	2
UCEC	VHL →	-0.647	-1.415	.001	.008	3	2
UCEC	ASNS →	+0.379	+1.280	<.001	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Caspase-7-cleavedD198 by MAMLD1 expression — UCEC

Explore this box plot interactively →