Across TCGA patient cohorts, MAML3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAML3-associated genes across cancer lineages are ASNS, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with MAML3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAML3-to-partner and partner-to-MAML3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAML3→partner) and Y-score (partner→MAML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.637	+2.815	.003	.036	2	4
UCEC	Cyclin-B1 →	+0.422	+1.440	.006	.022	3	3
UCEC	Caspase-7-cleavedD198 →	+0.362	+1.242	.028	.020	3	2
UCEC	eIF4E →	+0.148	+1.920	.011	.008	3	1
UCEC	ERK2 →	+0.157	+2.087	.003	.004	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.289	+1.179	.041	.041	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

MAML3 survival (RNA) · tumor vs normal (RNA) · all MAML3 data types