Across TCGA cell cohorts, MAML3 mutation is significantly associated with the RNA expression of many other genes, with 233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAML3-associated genes across cancer lineages are TMPRSS12, KRTAP3-1, and AVP. Each is linked with MAML3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAML3-to-partner and partner-to-MAML3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAML3→partner) and Y-score (partner→MAML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMPRSS12 →	+0.013	+4.882	.002	.001	3	2
SOFT_TISSUE	KRTAP3-1 →	+1.094	+4.417	<.001	.004	3	2
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
SKIN	SLC10A2 →	+0.002	+3.700	<.001	.009	3	2
LARGE_INTESTINE	MAGEB4 →	+0.007	+2.678	.001	.005	3	2
LARGE_INTESTINE	ELP5 →	+0.587	+2.502	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 233 associations by consensus.

Exploration

MAML3 survival (RNA) · tumor vs normal (RNA) · all MAML3 data types