Across TCGA patient cohorts, MAML2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAML2-associated genes across cancer lineages are 4E-BP1, ERK2, and MEK1. Each is linked with MAML2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAML2-to-partner and partner-to-MAML2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAML2→partner) and Y-score (partner→MAML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	4E-BP1 →	+0.652	+3.009	.001	.019	2	4
UCEC	ERK2 →	+0.177	+2.906	.002	.001	3	2
UCEC	MEK1 →	+0.376	+2.201	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.596	+2.267	<.001	<.001	3	2
COAD	4E-BP1_pT70 →	+0.150	+2.815	.022	.036	3	2
UCEC	14-3-3_beta →	-0.086	-1.738	.003	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

MAML2 survival (RNA) · tumor vs normal (RNA) · all MAML2 data types