MAML1

Across TCGA cell cohorts, MAML1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,401 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAML1-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Regulation of transcription initiation by RNA polymerase II, and Regulation of DNA-templated transcription initiation. Each is linked with MAML1 in more than 17 cancer types. Because this analysis shows association rather than direction, both MAML1-to-partner and partner-to-MAML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by MAML1-low versus MAML1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAML1→partner) and Y-score (partner→MAML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.099	+0.876	<.001	<.001	3	18
PANCREAS	Regulation of transcription initiation by RNA polymerase II →	+0.089	+0.847	<.001	<.001	3	18
PANCREAS	Regulation of DNA-templated transcription initiation →	+0.082	+0.838	<.001	<.001	3	18
BONE	Heterochromatin formation →	+0.091	+0.866	<.001	<.001	3	18
BONE	Establishment of mitotic spindle localization →	+0.136	+0.907	.001	<.001	3	17
BONE	Atrioventricular node cell differentiation →	+0.153	+0.626	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,401 associations by consensus.

Negative regulation of gene expression, epigenetic by MAML1 expression — BONE

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