MAML1

Across TCGA cell cohorts, MAML1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAML1-associated genes across cancer lineages are ADAM7, PZP, and C12orf65. Each is linked with MAML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAML1-to-partner and partner-to-MAML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by MAML1-low versus MAML1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAML1→partner) and Y-score (partner→MAML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAM7 →	+0.047	+4.285	<.001	.007	3	2
BLOOD_Myeloma	PZP →	+0.036	+4.807	<.001	.006	3	1
LARGE_INTESTINE	C12orf65 →	+0.728	+3.082	<.001	.007	3	1
LARGE_INTESTINE	SCLY →	+0.656	+3.064	.003	.009	3	1
LARGE_INTESTINE	FAM187B →	+0.019	+2.669	<.001	.004	3	1
LARGE_INTESTINE	ZNF771 →	+0.751	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ADAM7 by MAML1 expression — STOMACH

Explore this box plot interactively →