MAML1

Across TCGA cell cohorts, MAML1 mutation is significantly associated with the mutation status of many other genes, with 5,027 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAML1-associated genes across cancer lineages are SLIT3, RADIL, and NID1. Each is linked with MAML1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAML1-to-partner and partner-to-MAML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLIT3 grouped by MAML1-low versus MAML1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAML1→partner) and Y-score (partner→MAML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLIT3 →	+3.942	+4.584	.002	.002	1	4
SKIN	RADIL →	+3.392	+4.718	.002	.002	1	4
BLOOD_Leukemia	NID1 →	+2.758	+2.493	.007	.007	1	4
LARGE_INTESTINE	SPEG →	+1.637	+3.823	<.001	<.001	1	4
CNS	RHOA →	+5.044	+5.614	.003	.003	1	4
BLOOD_Leukemia	SSTR5 →	+3.495	+2.880	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,027 associations by consensus.

SLIT3 by MAML1 expression — STOMACH

Explore this box plot interactively →