MAMDC4

Across TCGA patient cohorts, MAMDC4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAMDC4-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and A-Raf_pS299. Each is linked with MAMDC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAMDC4-to-partner and partner-to-MAMDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAMDC4-low versus MAMDC4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMDC4→partner) and Y-score (partner→MAMDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.313	+3.467	<.001	.002	3	3
COAD	EGFR_pY1068 →	-0.356	-3.000	.016	.034	3	2
UCEC	A-Raf_pS299 →	-0.227	-3.700	<.001	.001	3	1
UCEC	ERK2 →	+0.297	+3.807	<.001	<.001	3	1
UCEC	GAPDH →	+0.450	+1.874	.042	.049	3	1
UCEC	GATA6 →	-0.184	-2.444	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by MAMDC4 expression — COAD

Explore this box plot interactively →