MAMDC2

Across TCGA cell cohorts, MAMDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,253 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MAMDC2-associated GO terms across cancer lineages are Blood coagulation, fibrin clot formation, Cortisol metabolic process, and Protein activation cascade. Each is linked with MAMDC2 in more than 10 cancer types. Because this analysis shows association rather than direction, both MAMDC2-to-partner and partner-to-MAMDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blood coagulation, fibrin clot formation grouped by MAMDC2-low versus MAMDC2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMDC2→partner) and Y-score (partner→MAMDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Blood coagulation, fibrin clot formation →	+0.435	+1.484	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Cortisol metabolic process →	-1.305	-1.754	<.001	<.001	3	11
BREAST	Protein activation cascade →	+0.373	+1.381	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Maintenance of protein localization in organelle →	+0.103	+1.550	<.001	.005	3	10
LUNG_NSCLC_LUSC	Regulation of fibrinolysis →	+0.357	+2.471	.001	<.001	3	9
OESOPHAGUS	Nuclear membrane organization →	+0.089	+1.086	<.001	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,253 associations by consensus.

Blood coagulation, fibrin clot formation by MAMDC2 expression — BREAST

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