MAMDC2

Across TCGA cell cohorts, MAMDC2 mutation is significantly associated with the mutation status of many other genes, with 3,494 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAMDC2-associated genes across cancer lineages are PREP, NYNRIN, and ZNF865. Each is linked with MAMDC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAMDC2-to-partner and partner-to-MAMDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREP grouped by MAMDC2-low versus MAMDC2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMDC2→partner) and Y-score (partner→MAMDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PREP →	+4.977	+4.415	.007	.007	1	4
CNS	NYNRIN →	+4.044	+5.000	.008	.008	1	4
BLOOD_Leukemia	ZNF865 →	+2.350	+3.055	.006	.006	1	4
BLOOD_Leukemia	USP34 →	+2.465	+3.156	.005	.005	1	4
BLOOD_Leukemia	ZFC3H1 →	+2.880	+3.495	.002	.002	1	4
BLOOD_Leukemia	DRD3 →	+5.050	+4.000	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,494 associations by consensus.

PREP by MAMDC2 expression — OVARY

Explore this box plot interactively →