MAMDC2

Across TCGA cell cohorts, MAMDC2 mutation is significantly associated with the drug of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAMDC2-associated genes across cancer lineages are AGI-6780, Bromosporine, and Eg5_9814. Each is linked with MAMDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAMDC2-to-partner and partner-to-MAMDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGI-6780 grouped by MAMDC2-low versus MAMDC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAMDC2→partner) and Y-score (partner→MAMDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGI-6780 →	+0.474	+3.061	.006	.010	3	2
LARGE_INTESTINE	Bromosporine →	+0.438	+2.710	.004	.027	3	1
LARGE_INTESTINE	Eg5_9814 →	+0.669	+3.000	.010	.021	3	1
LARGE_INTESTINE	TAK-715 →	+0.508	+2.722	.006	.023	3	1
LARGE_INTESTINE	WYE-125132 →	+0.477	+3.067	.040	.009	3	1
LARGE_INTESTINE	Sphingosine Kinase 1 Inhibitor II →	+0.233	+3.201	.022	.006	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

AGI-6780 by MAMDC2 expression — LARGE_INTESTINE

Explore this box plot interactively →