MALT1

Across TCGA pan-cancer cohorts, MALT1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MALT1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MALT1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MALT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where MALT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.750	1.000	.031	12	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.010	9	view →
HNSC	DFS	Tertile	II,III,IV	0.986	0.873	.017	8	view →
LSCC	DFS	Tertile	III,IV	1.000	0.445	.016	6	view →
GBM	OS	Quartile	All	0.258	0.532	.019	4	view →
PDAC	OS	Tertile	IV	0.934	0.395	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MALT1–CCRCC (OS)

Open the CCRCC breakdown →