MALT1

Across TCGA patient cohorts, MALT1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MALT1-associated genes across cancer lineages are PKC-delta_pS664, EGFR_pY1068, and A-Raf_pS299. Each is linked with MALT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MALT1-to-partner and partner-to-MALT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by MALT1-low versus MALT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MALT1→partner) and Y-score (partner→MALT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.110	-2.105	.022	.017	3	3
UCEC	EGFR_pY1068 →	-0.414	-3.087	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.196	-3.584	<.001	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.146	-2.115	.003	.016	3	1
UCEC	IGFBP2 →	-0.586	-1.906	.025	.016	3	1
UCEC	ACVRL1 →	-0.149	-3.446	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PKC-delta_pS664 by MALT1 expression — UCEC

Explore this box plot interactively →