MALT1

Across TCGA cell cohorts, MALT1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MALT1-associated genes across cancer lineages are ALLC, SLCO1C1, and ECE2. Each is linked with MALT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MALT1-to-partner and partner-to-MALT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALLC grouped by MALT1-low versus MALT1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MALT1→partner) and Y-score (partner→MALT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ALLC →	+0.182	+4.050	.006	.002	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.413	+3.772	<.001	.003	3	1
LARGE_INTESTINE	ECE2 →	+0.252	+3.376	.001	.002	3	1
LARGE_INTESTINE	TKTL2 →	+0.046	+4.187	<.001	.002	3	1
LARGE_INTESTINE	ARL13A →	+0.062	+3.369	.007	.007	3	1
LARGE_INTESTINE	OR4F21 →	+0.163	+2.878	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ALLC by MALT1 expression — URINARY_TRACT

Explore this box plot interactively →