MAL2-AS1

Across TCGA pan-cancer cohorts, MAL2-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MAL2-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MAL2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAL2-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

UVM, COAD, and ESCA are the cancer types where MAL2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.337	0.829	<.001	54	view →
COAD	DFS	Tertile	II,III,IV	0.443	0.753	<.001	52	view →
ESCA	OS	Quartile	II,III,IV	0.303	0.731	.001	40	view →
DLBC	OS	Tertile	All	0.053	0.936	<.001	33	view →
THYM	OS	Quartile	II,III,IV	0.650	0.954	.001	30	view →
GBM	DFS	Tertile	All	0.131	0.275	<.001	27	view →
KIRC	DFS	Median	All	0.802	0.919	.005	22	view →
UCEC	OS	Median	All	0.555	0.780	.001	22	view →
KIRP	OS	Median	III,IV	0.184	0.784	.003	16	view →
OV	DFS	Tertile	IV	0.378	0.651	.009	12	view →
HNSC	OS	Median	All	0.820	0.716	.019	12	view →
BRCA	DFS	Median	II,III,IV	0.432	0.614	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MAL2-AS1–UVM (DFS)

Open the UVM breakdown →