MAL

Across TCGA cell cohorts, MAL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,276 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAL-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Positive regulation of post-translational protein modification, and Energy derivation by oxidation of organic compounds. Each is linked with MAL in more than 6 cancer types. Because this analysis shows association rather than direction, both MAL-to-partner and partner-to-MAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by MAL-low versus MAL-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAL→partner) and Y-score (partner→MAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of mRNA splicing, via spliceosome →	+0.058	+2.259	.001	.002	3	7
OVARY	Positive regulation of post-translational protein modification →	+0.055	+3.248	.001	.002	3	7
OVARY	Energy derivation by oxidation of organic compounds →	+0.052	+2.611	<.001	<.001	3	6
LARGE_INTESTINE	Symbiont entry into host →	+0.052	+0.146	.001	.002	3	6
LARGE_INTESTINE	Symbiont entry into host cell →	+0.052	+0.146	.001	.002	3	6
OVARY	Protein stabilization →	+0.066	+3.474	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,276 associations by consensus.

Regulation of mRNA splicing, via spliceosome by MAL expression — KIDNEY

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