Across TCGA patient cohorts, MAK16 mutation is significantly associated with the RNA expression of many other genes, with 1,692 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAK16-associated genes across cancer lineages are RNA5SP198, RPL17P49, and VTRNA2-2P. Each is linked with MAK16 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAK16-to-partner and partner-to-MAK16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAK16→partner) and Y-score (partner→MAK16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.284	+5.144	<.001	.003	3	2
CESC	RPL17P49 →	+0.101	+5.342	<.001	.002	3	2
CESC	VTRNA2-2P →	+0.417	+4.601	<.001	.004	3	2
SKCM	PEX12P1 →	+0.058	+6.555	<.001	<.001	3	2
UCEC	RN7SL237P →	+0.299	+2.496	<.001	<.001	3	2
UCEC	MIR4422 →	+0.307	+2.613	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,692 associations by consensus.

Exploration

MAK16 survival (RNA) · tumor vs normal (RNA) · all MAK16 data types