MAK16

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MAK16 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAK16-associated genes across cancer lineages are eEF2, ERK2, and PCNA. Each is linked with MAK16 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAK16-to-partner and partner-to-MAK16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAK16→partner) and Y-score (partner→MAK16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeEF2 →+0.489+2.321<.001.00632
UCECERK2 →+0.232+2.000.003.02932
UCECPCNA →+0.261+3.169.003.01832
UCECPDCD4 →-0.688-3.459<.001.00532
UCECShc_pY317 →-0.213-1.874<.001.04932
UCECBax →+0.246+3.331.013.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

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