MAJIN

Across TCGA patient cohorts, MAJIN mutation is significantly associated with the RNA expression of many other genes, with 834 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAJIN-associated genes across cancer lineages are OR9Q2, RNASEH2A, and KXD1. Each is linked with MAJIN in more than 2 cancer types. Because this analysis shows association rather than direction, both MAJIN-to-partner and partner-to-MAJIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9Q2 grouped by MAJIN-low versus MAJIN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAJIN→partner) and Y-score (partner→MAJIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR9Q2 →	+0.014	+3.993	<.001	.008	3	3
SKCM	RNASEH2A →	+0.752	+3.227	<.001	.009	3	2
UCEC	KXD1 →	+0.470	+3.732	.001	<.001	3	2
SKCM	BIRC8 →	+0.032	+2.577	<.001	.007	3	2
UCEC	SAAL1 →	+0.545	+2.606	.005	.006	3	2
UCEC	PGP →	+0.550	+3.700	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 834 associations by consensus.

OR9Q2 by MAJIN expression — SKCM

Explore this box plot interactively →