MAIP1

Across TCGA patient cohorts, MAIP1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAIP1-associated genes across cancer lineages are PDCD4, STAT3_pY705, and TIGAR. Each is linked with MAIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAIP1-to-partner and partner-to-MAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MAIP1-low versus MAIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAIP1→partner) and Y-score (partner→MAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.836	-3.000	.002	.037	3	1
UCEC	STAT3_pY705 →	-0.464	-3.000	.002	.037	3	1
UCEC	TIGAR →	+0.175	+3.026	.047	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.899	+2.827	.008	.035	3	1
UCEC	C-Raf_pS338 →	-0.116	-3.000	.013	.037	3	1
UCEC	Akt_pS473 →	-0.823	-3.000	.046	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PDCD4 by MAIP1 expression — UCEC

Explore this box plot interactively →